Skills

I have a lot of skills. I am naturally sociable, I can hold my breath for 1 min or say hello in at least 5 different languages 😃. But below are the main ones:

R

Fully familiar with it even if a lot remains to be learnt.

Bash

I know just enough to write a simple bioinfomartic pipeline or parse a file

Statistics

I know the basics, but I can do whatever is described in a well documented R package or a R tuto.

Lab work

Mosquito rearing, cell, parasite and virus culture, sequencing among many others…

Vectorial drawing

Vectorial drawing is my special hobby. I am not very good at it but I enjoy it.

Experience

 
 
 
 
 
September 2016 – Present
IRBA, Marseille, France

Research scientist

Unité de Parasitologie et Entomologie, French Armed Forces Biomedical Research Institute (IRBA)

Area of interest :

  • Assess dynamic processes related to vector competence or other mosquito-related traits.
  • Determine the genetic basis of mosquito vectors related phenotypes.
  • A lot of other cool stuffs applied to vector borne diseases that can involve genetic, genomic, dynamic data and fancy data visualisation :)
 
 
 
 
 
January 2012 – August 2016
Institut Pasteur, Paris, France

Postdoctoral researcher

G5 Insect virus-interactions, headed by Louis Lambrechts

Quantitative genetic and genomic work on the Aedes aegypti mosquito, the main vector of dengue or zika virus. I also worked on intra-host infection dynamic.
 
 
 
 
 
January 2007 – March 2011
IMTSSA, Marseille, France

Doctoral researcher

Unité de Recherche en Biologie et Epidemiologie Parasitaires (URBEP), Institut de Médecine Tropicale du Service de Santé des armées (IMTSSA), Marseille, France

Use of anti-mosquito saliva antibody responses to evaluate exposure to specific species of mosquito vectors. (“http://www.theses.fr/fr/2011AIX20661")

Selected Publications

We revealed that Ae. geniculatus is highly susceptible to CHIKV infection and could transmit the virus. By specifically exploring the vector competence dynamic in Ae. geniculatus and Ae. albopictus mosquito species, we revealed that the cumulative distribution of CHIKV incubation period in Ae. geniculatus was delayed by several days as compared to Ae. albopictus.
In Emerg Microbes Infect., 2019

We participated to this study by illustrating the value of the new assembly (AaegL5) for mapping quantitative trait loci (QTLs). We used restriction site-associated DNA (RAD) markers to locate QTLs underlying dengue virus (DENV) vector competence.
In Nature, 2018

In this study, we estimated ZIKV incubation period distribution using time-to-event models adapted to interval-censored data based on declared date of travels from 123 symptomatic travelers returning from areas with active ZIKV transmission.
In OFID, 2018

We combined newly generated empirical measurements in vivo and outbreak simulations in silico to assess the epidemiological significance of genetic variation in dengue virus (DENV) transmission kinetics by Aedes aegypti mosquitoes. We used a logistic model with three-parameters to estimate intra-mosquito virus dynamics based on the cumulative proportion of mosquitoes experimentally exposed to DENV with a systemic (disseminated) infection over time.
In PLoS pathog, 2018

We provide evidence that sex chromosomes in Ae. aegypti are genetically differentiated between males and females over a region much larger than the sex-determining region (SDR). Our linkage mapping intercrosses failed to detect recombination between X and Y chromosomes over a 123-Mbp region (40% of their physical length) containing the SDR. Sex-differentiated genomic region was associated with a significant excess of male-to-female heterozygosity and contained a small cluster of loci consistent with Y-specific null alleles.
In GBE, 2017

We report that individual Aedes aegypti mosquitoes release large amounts of dengue virus (DENV) RNA in their excreta that can be non-sacrificially detected over time following oral virus exposure. Further, we demonstrate that detection of DENV RNA in excreta from individual mosquitoes is correlated to systemic viral dissemination.
In Sci Rep, 2016

We developed an innovative genetic mapping strategy to survey G×G interactions using outbred mosquito families that were experimentally exposed to genetically distinct isolates of two dengue virus serotypes derived from human patients. Genetic loci associated with vector competence indices were detected in multiple regions of the mosquito genome. Importantly, correlation between genotype and phenotype was virus isolate-specific at several of these loci, indicating G×G interactions.
In PLoS genet, 2013

This paper provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins characterised in various haematophagous arthropod species. The potential biological and epidemiological applications of these immunogenic salivary molecules are discussed with an emphasis on their use as biomarkers of exposure to haematophagous arthropod bites or vaccine candidates that are liable to improve host protection against vector-borne diseases.
In Parasit vectors, 2011

Recent Publications

We revealed that Ae. geniculatus is highly susceptible to CHIKV infection and could transmit the virus. By specifically exploring the …

We participated to this study by illustrating the value of the new assembly (AaegL5) for mapping quantitative trait loci (QTLs). We …

In this study, we estimated ZIKV incubation period distribution using time-to-event models adapted to interval-censored data based on …

We combined newly generated empirical measurements in vivo and outbreak simulations in silico to assess the epidemiological …

We provide evidence that sex chromosomes in Ae. aegypti are genetically differentiated between males and females over a region much …

We report that individual Aedes aegypti mosquitoes release large amounts of dengue virus (DENV) RNA in their excreta that can be …

We developed an innovative genetic mapping strategy to survey G×G interactions using outbred mosquito families that were experimentally …

This paper provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins …

Behind the papers: Tutorials

You are willing to learn how to code in R but you are not familiar with this code? You don’t even know what R or a computing language …

Background A endpoint dilution assay quantifies the amount of a test substance (ie. drug, toxin, pathogen, etc…) that produces an …

Background Aedes gunganiensis, a mosquito species native of Naboo planet, was suspected to be the main vector of the mysterious virus …

Background A mysterious disease has emerged on planet Naboo. Both infected humans and other extra-terrestrial life forms experience …

A major turnover in my young scientist career was to learn how to code in the R environment. R brought my science abilities to a next …

Contact

  • Unité de Parasitologie et Entomologie, IHU - Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France